Trimethyl orthoformate (TMOF) is the organic compound with the formula HC(OCH3)3. A colorless liquid, it is the simplest orthoester. It is a reagent used in organic synthesis for the formation of methyl ethers. The product of the reaction of an aldehyde with trimethyl orthoformate is acetal.
The TMOF is a key organic synthesis intermediate, lt is mainly used to synthesize azoxystrobin and some other pesticides. For medical aspect, it is used to synthesize pipemidic acid, vitamins, cephalo-type antibiotics, etc, lt is also widely used in coating, dye, and perfume industries.
|Odour||Pungent, Aromatic, ester-like|
|Melting point/Freezing Point||-53℃|
|Boiling Point||101-102 °C|
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